VEGFC and lip and oral cavity carcinoma: Similarly, among 461 betel-quid consumers, subjects with VEGF-C polymorphic rs3775194, rs11947611 or rs7664413, genes and who smoked had corresponding risks of 2.695- (95% CI: 1.270∼10.750), 8.066- (95% CI: 2.250∼28.913), and 18.100-fold (95% CI: 5.427∼60.369) of having oral cancer compared to betel-quid chewers with the WT gene who did not smoke (Table 4).