VEGF-C is frequently identified in tumor tissues within head and neck squamous cell carcinoma, and the broad expression of the VEGF-C/VEGFR-3 axis in head and neck squamous cell carcinoma suggests involvement in tumor lymphangiogenesis and angiogenesis, promoting tumor growth, and propagation of cancer cells [46]. The gene discussed is FLT4; the disease is head and neck squamous cell carcinoma.