Although we do not know which SNAP-25 isoforms are associated with ADHD, it is important to note that the SNAP-25 motif (AA 7–83 and 141–204) that is critical to SNARE formation and the exon 5 splice variant described above, all lie within the ADHD-associated region described herein. This evidence concerns the gene SNAP25 and attention deficit-hyperactivity disorder.