Furthermore, Nherf1 was reported to localize to pseudopodial tips along with NHE1 and stimulate NHE1 activity, leading to increased invasiveness of breast cancer cells [96], and loss of Nherf1 enhances Wnt/β-catenin signaling, which is associated with hyperproliferation in breast cancer [68]. Here, NHERF1 is linked to breast cancer.