Two common SNPs in ERCC1, the synonomous 11615 at exon 4 (Asn118Asn), and rs3212986 located at the 3′-untranslated region of ERCC1 (C8092A) have been associated with an increase risk to develop lung cancer [9]–[12], squamous cell carcinoma of the head and neck (SCCHN) [13], [14], basal cell carcinoma (BCC) [15]–[17], breast cancer [18], [19] and colorectal cancer [20]. This evidence concerns the gene ERCC1 and head and neck squamous cell carcinoma.