A significant positive association with MS and five DRB1-DQB1 HLA haplotypes, including the *13∶03-*03∶01, *04∶05-*03∶01, *03∶01-*02∶01, *04∶05-*03∶02 and *15∶01-*06∶02 have been reported in the Sardinian population, with different ranges of risk carried by patients/individuals with each associated haplotype [16]. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.