With the MMP16 and EGFR, men with the genotype combination of GA/AA and AA in a SNP pair of rs1401862 and rs6964705 tended to be less likely (OR = 0.58, p-value = 0.011) have aggressive prostate cancer than other genotype combinations of the SNP pairs in the CGEMS group. The gene discussed is EGFR; the disease is Familial prostate cancer.