Among men carrying two T alleles at rs2710647 in EH domain binding protein 1 (EHBP1), the risk of prostate cancer in those with low malathion use was 2.17 times those with no use (95% CI: 0.91, 5.14) and in those with high malathion use was 3.43 times those with no use (95% CI: 1.44–8.15) (P-interaction  = 0.003). This evidence concerns the gene EHBP1 and prostate carcinoma.