The role of genetic variation in IL6R in the etiology of human disease has been highlighted by genetic studies reporting the association of variants in the gene with the risk of several diseases with an inflammatory component, including coronary heart disease (CHD) [5]–[7], rheumatoid arthritis (RA) [8], atrial fibrillation (AF) [9], abdominal aortic aneurysm (AAA) [10] and asthma [11]. Here, IL6R is linked to atrial fibrillation.