Interestingly, interrupting Parp1's function has been shown to be protective in several other models of neuronal damage including ischemia/reperfusion and glutamate excitotoxity [72]–[74], and retinal degeneration induced by ischemia/reperfusion or by treatment with PDE6 inhibitor, which mimics the rd1 mutation [75], [76]. Here, PARP1 is linked to retinal degeneration.