SNRPN and Angelman syndrome: Importantly, our observations at the Snrpn domain recapitulate the molecular signatures of Angelman Syndrome (AS) in humans, of which a significant proportion of cases are caused by absence of the E3A ubiquitin ligase gene UBE3A product due to mutation or epigenetic aberrations at the SNRPN imprinting center (IC) in the brain [39], [40].