Similarly, the ncRNA vault RNA2-1 (vtRNA2-1) in the commonly deleted region of chromosome 5q is monoallelically methylated and expressed in healthy individuals, while it is epigenetically inactivated in AML, leading to activation of NF-kB via RNA-binding protein kinase R (PKR, [82]). Here, EIF2AK2 is linked to acute myeloid leukemia.