Genome- and exome-wide analyses of CLL cells have recently shown that mutations are present in genes involved in NF-kB signalling [90], and intriguingly mutations in a NF-kB-pathway associated gene (MYD88, Gene ID: 4615) seem to be even enriched in del(13q) patients [91]. The gene discussed is MYD88; the disease is B-cell chronic lymphocytic leukemia.