NFKB1 and B-cell chronic lymphocytic leukemia: The speculative involvement of 13q14 genes in negative B-cell selection could explain how deletion of NF-kB-inducing genes at 13q14 would lead to CLL leukemogenesis at an early timepoint, while malignant B-cells from of terminal stage CLL then exhibit increased levels of NF-kB that prevent apoptosis as has been shown previously (see above).