HIV-1 capture by DCs and access to the DC-dependent trans infection pathway has long been thought to be exclusively dependent on the interactions of the mannosylated virus envelope glycoprotein gp120 with C-type lectin receptors (CLRs) [4], such as dendritic cell-specific intercellular adhesion molecule-3-binding nonintegrin (DC-SIGN) [5]. Here, ERVW-1 is linked to infection.