HMGCR and cytomegalovirus infection: Figure 4 shows that HCMV infection induces expression of ACC1, ACL, FAS, and HMGCR in cells treated with shGFP, confirming previous results [5]. However, the induction of these mRNAs by HCMV infection was substantially inhibited in PERK depleted cells (Fig. 4). The data in Figure 3 and 4 indicate that PERK is necessary for the full induction of lipogenesis in HCMV-infected cells.