Interestingly, neither the precursor nor the mature form of SREBP2 were affected by PERK depletion in mock- and HCMV-infected cells (Fig. 5D), indicating that SREBP1 and SREBP2 are cleaved by different mechanisms in HCMV infection, and PERK is necessary for the cleavage of SREBP1 only. The gene discussed is SREBF1; the disease is cytomegalovirus infection.