Our study describes two different aspects of Cav1's role in stomach disease: (i) first, an in vivo protective role against H. pylori-induced inflammation which was independent of CagA/VacA, and (ii) second, an in vitro protective role against H. pylori-induced cytoskeletal rearrangement which was dependent on CagA and DLC1. Here, DLC1 is linked to stomach disorder.