CD8A and myeloid sarcoma: A cytotoxic attack toward EBV infected cells in the MS brain is consistent with enrichment in EBV-specific CD8+ T cells in the cerebrospinal fluid (CSF) of patients with early MS [53], with increased CSF levels of granzymes during relapse in relapsing-remitting MS patients [54], and with preferential expansion of CD8+ T cells in MS brain lesions and CSF [55], [56].