In contrast, pioglitazone-treated mice not only recovered from colitis and its associated weight loss, but also showed a switch from a predominant Th17 into an iTreg phenotype characterized by increased expression of FOXP3 and decreased IL17-A and RORγt in CD4+ T cells of the colonic LP and MLN (Figure 5D and 5E and Figure S13). Here, CD4 is linked to colitis.