This region contains a putative amyloidogenic motif (residues F515-N532) reported previously [57] and, therefore, may be involved in the amyloid formation in the variant of LCD type 1 caused by the A546D mutation in TGFBI. However, further studies are required to determine the specific roles of these FAS1–4 domain regions in the pathobiology of TGFBIp-linked corneal amyloidosis. The gene discussed is TGFBI; the disease is gelatinous drop-like corneal dystrophy.