GJA3 and cataract: In this study, we localized the candidate gene of a four-generation Chinese congenital coralliform cataract pedigree in the GJA3 locus and identified a novel insertional mutation (c.1361_1362insC) of GJA3. This insertion mutation is the second reported mutation of GJA3 to have been localized to the intracellular C-terminus, indicating that the C-terminus plays an essential role in GJA3 gene function.