HMOX1 and infarction: Although we and others have previously demonstrated that acute HO-1 upregulation occurs in response to ischemic injury in several organs, including the heart (Masini et al., 2003; Giannini et al., 2005; Lakkisto et al., 2009; Yeh et al., 2009), here we show for the first time that selective and prolonged pharmacological induction of HO-1 activity significantly ameliorates post-infarction myocardial remodeling.