PIK3CA and cancer: When looking at nine canonical signaling pathways (PI3K/AKT/mTOR, MAPK, TGF-B, p38/MAPK, JNK, JAK/STAT, WNT/β-Catenin, and NFκB) and copy number variation in terms of patient survival, the PI3K/AKT/mTOR pathway was the most frequently altered cancer related pathway [36].