CASP8 and ovarian cancer: For the ovarian cancer study of the NF-κB pathway, we identified 13 statistically significant (lFDR<0.05) gene pairs of interest (Table 3) in applying our KCCA method, using the trimmed jackknife SE estimate with ω=0.15, with the top coassociated gene pair with case-control status occurring between CASP8 and MAP3K3. Application of the CCA-based procedure resulted in 37 significant gene pairs; however, none of these overlapped with those detected by the KCCA method.