The serum levels of FRA, MSLN, CA125 and HE4 readily discriminated between serous ovarian cancer and control serum samples (Figure 7), with p-values of <0.0001 for FRA, MSLN and CA125, and 0.0002 and 0.0012 for HE4 and MPF, respectively. This evidence concerns the gene WFDC2 and ovarian serous adenocarcinoma.