One such biomarker is folate receptor alpha (FRA), a glycosylphosphatidylinositol (GPI)-anchored protein involved in folate transport into cells that is expressed in breast, lung, clear cell renal, ovarian and endometrial carcinomas, and non-small cell lung adenocarcinoma [39-58]. This evidence concerns the gene FOLR1 and non-small cell lung adenocarcinoma.