ROC curve analysis resulted in AUCs of 0.80 (p<0.0001) for FRA and MSLN (p<0.0001) and 0.641 (p=0.0007) for MPF (Figure 3) suggesting that FRA and MSLN have greater potential with respect to discrimination of individuals with ovarian cancer compared to normal individuals, independent of other clinical variables. Here, MSLN is linked to ovarian cancer.