Thus, the chemopreventative efficacy of the most effective combination DMAPT/gemcitabine was further evaluated in this survival study using the LSL-KrasG12D/+; LSL-Trp53R172H; Pdx-1-Cre mouse model, which is characterized by near 100% incidence of pancreatic adenocarcinoma development. The gene discussed is PDX1; the disease is pancreatic adenocarcinoma.