ACE and familial pancreatic carcinoma: Similarly, Fendrich et al. recently showed that treatment with the angiotensin-I-converting enzyme inhibitor enalapril or aspirin, that targets NF-κB, delays PanIN progression in LSL-KrasG12D; Pdx-1-Cre mice and decreases pancreatic cancer development in the LSL-KrasG12D/+; LSL-Trp53R172H; Pdx-1-Cre mouse [36].