In this study, gemcitabine alone and/or the combination of DMAPT and gemcitabine significantly increase median survival as well as decrease tumor size, the incidence and multiplicity of pancreatic tumors, and metastasis to the liver in LSL-KrasG12D/+; LSL-Trp53R172H; Pdx-1-Cre mice. Here, PDX1 is linked to neoplasm.