FGF21 and cholangiocarcinoma: This was also evident in cholangiocellular carcinoma with bile duct epithelium proliferation (yellow arrows) (Figure 7A) and clear cell-type hepatocellular carcinoma (Figure 7C) with no or weak FGF21 expression in tumor cells; however, FGF21 was highly expressed in fields adjacent to tumors (Figure 7B, D) and in phenotypically normal hepatocytes (as represented in Figure 6H).