Recent evidence also suggests that platelets may play a more active role in promoting metastatic spread outside of the primary tumour’s microenvironment by active signalling to tumour cells through the TGF-B and NF-Kb pathways resulting in a pro-metastatic phenotype that facilitates tumour cell extravasation and metastasis formation [31], and aspirin is known to inhibit the activation of NF-Kb [32]. This evidence concerns the gene TGFB1 and neoplasm.