MKI67 and neoplasm: Consistently, immunohistochemistry revealed that CB-PIC treatment attenuated the expression of expression of Ki-67(proliferation), CD34 (blood vessel density), and carbonic anhydrase(CA)IX (hypoxic marker) and increased pAMPKα index in the tumor sections of CB-PIC-treated group (50 mg/kg) compared to untreated control (Figure 7(d)).