Furthermore, CB-PIC suppressed the expression of hypoxia inducible factor 1 (HIF1) alpha as a hypoxia master regulator [33], Akt, and mammalian target of rapamycin (mTOR) similar to AMPK activator metformin in hypoxic SW620 cells, implying the important roles of mammalian target of rapamycin (mTOR) and AMPKα signaling in cancer metabolism [34, 35]. The gene discussed is AKT1; the disease is cancer.