Skin lesions associated with atopic dermatitis (AD) are frequently colonized by Staphylococcus aureus (S. aureus) [23], which secrete two kinds of major staphylococcal enterotoxins A (SE), staphylococcal enterotoxin (SEA) and staphylococcal enterotoxin B (SEB), that are characteristic of staphylococcal superantigens (SsAgs) and bind to major histocompatibility complex class II molecules and selectively activate T cells expressing certain T cell receptor (TCR) Vβ-chain families. This evidence concerns the gene SETBP1 and Alzheimer disease.