For example, the muscle wasting seen in the Yoshida hepatoma ascites model is generally considered to be the result of elevations in TNF-α while muscle loss in the colon-26 adenocarcinoma tumor implant model has been shown to be associated with increases in the amount of IL-1, IL-6, IL-12 and TNF-α (15–17). This evidence concerns the gene IL6 and neoplasm.