In the experiment of HAK-1B tumors, the tumor volume of mice receiving PEG-IFN-α2b, sorafenib, and sorafenib+PEG-IFN-α2b was 34, 73 and 36%, respectively, of the control volume and the tumor weight was 23, 71 and 34%, respectively, of the control weight. The gene discussed is IFNA2; the disease is neoplasm.