In the experiment of KIM-1 tumors, the tumor volume of mice receiving PEG-IFN-α2b, sorafenib, and sorafenib+PEG-IFN-α2b was 69, 45 and 46%, respectively, of the control volume and the tumor weight was 75, 41 and 37%, respectively, of the control weight. This evidence concerns the gene IFNA1 and neoplasm.