We found an aggravation of the impact of acute exposure to DEP in diabetic mice substantiated by increase of systemic inflammation (leukocytosis and CRP), oxidative stress (8-isoprostane), hypoxemia, hepatotoxicity and acceleration of coagulation comprising thrombosis in vivo, platelet aggregation in vitro, and the increase in plasma concentrations of PAI-1 and vWF. The gene discussed is SERPINE1; the disease is Increased total leukocyte count.