AKT1 and neoplasm: In addition, our group has demonstrated that p-AKT is expressed in a high percentage of FMCs and correlated to poor prognosis[22], suggesting that the PI3K/AKT/mTOR pathway is activated and associated with oncogenesis in the feline species, which is similar to that in humans[14] and recently also demonstrated in canine tumour cells[39] These assumptions prompted us to better understand the involvement of mTOR in FMC.