Two perilipins have been characterized in flies [29]: Lsd-2 promotes fat storage as mutants of Lsd-2 are lean and starvation sensitive [30]; and perilipin-1 mutants display adult onset obesity and hyperphagia [31], suggesting a role for this molecule in controlled access of the lipid droplets to lipolytic enzymes. This evidence concerns the gene KDM1B and obesity due to melanocortin 4 receptor deficiency.