The up-regulated genes in tumour group 1 were involved mainly in following pathways: 5HT1 receptor, apoptosis, β1 and β2 adrenergic receptors, G protein, GABA-B receptor, H2 histamine receptor, metabotropic II and III receptor, acetylocholine M2 and M4 receptor, P53, PDGF and RAS (Table 2). This evidence concerns the gene HRH2 and neoplasm.