As a recent example, the NSCLC INTEREST study comparing gefitinib to docetaxel concluded that the two therapies were equivalent [28], but gefitinib gave a higher response rate and longer PFS than docetaxel in patients with EGFR mutations, while there was a trend towards docetaxel giving more responses and longer PFS in EGFR-wild-type patients [29]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.