However, we observed that the level of UBE2C protein expression was positively correlated with tumor size (T classification) (T1–T2 vs. T3–T4, P=0.017), lymph node metastasis (N classification) (N0 vs. N1–N3) (P=0.016) and distant metastasis (M classification) (M0 vs. M1, P=0.015) in NPC patients (Table 2). This evidence concerns the gene UBE2C and nasopharyngeal carcinoma.