Consequently, we examined UBE2C expression in variously differentiated NPC cell lines in vitro. The results showed that immortalized nasopharyngeal NP-69 cells displayed low level of UBE2C expression; however, UBE2C was universally expressed in a variety of NPC cell lines, and its expression levels were reversely related to the stages of differentiation. The gene discussed is UBE2C; the disease is nasopharyngeal carcinoma.