As pointed out in an accompanying mini-review at the time [47], perhaps the biggest impact of our paper and the others linking LKB1 and AMPK [1-3] came from the link they established between a tumor suppressor (LKB1) with roles in cancer, and a protein kinase (AMPK) that had previously been regarded as a regulator of metabolism, with clinical implications in diabetes but not in cancer. This evidence concerns the gene PRKAA1 and cancer.