STK11 and lung adenocarcinoma: In a study of LKB1-deficient lung adenocarcinoma (A549) cells, it was found that re-expression of LKB1 protected the cells against cell death induced by glucose starvation, apparently through inhibition of fatty acid synthesis by AMPK and consequent sparing of NADPH, which could be utilized to provide protection against the oxidative stress induced by glucose deprivation [88].