The ability of CRH to regulate cell apoptosis in several cells of different origin has been reported [33,34], and CRH has been shown to induce FASLG (Fas ligand) production and apoptosis in the rat pheochromocytoma cell line PC12 via activation of MAPK (p38 mitogen-activated protein kinase) [22]. The gene discussed is FASLG; the disease is hereditary pheochromocytoma-paraganglioma.