Like ordinary pheochromocytoma/paraganglioma, most cases of composite pheochromocytoma/paraganglioma were functional, with increased level of catecholamines or corticotropin-releasing hormone (CRH) [10] or their metabolites or whatever, and over 62% of the patients were also hypertensive [3]. The gene discussed is CRH; the disease is hereditary pheochromocytoma-paraganglioma.