Univariate analysis expression with regard to RFS, using the Cox proportional hazard regression model, showed that hK6 expression, TNM stage, tumor size, T stage, lymph lodes, margin and were influencing factors for RFS, When hK6 expression along with other factors were examined in a multivariate model, TNM stage, hK6 expression, tumor size, margin were independent predictors of tumor recurrence (Table 3), indicating hK6 positive patients are twice more likely to have a recurrence than hK6 negative ones. This evidence concerns the gene KLK6 and neoplasm.