CAV1 and cancer: It may also explain the higher incidence of cancer before the age of 40, as those individuals with the “more aged” LFS phenotype (shorter telomeres, fibroblastic cells more likely to move into senescence and autophagy, higher levels of basal oxidative stress, greater loss of cav-1) develop cancer at a younger age than those with a more normal telomeric profile (a “less aged” phenotype).