In addition, some patients reduce their normal insulin dose after an episode, thus potentially compromising their diabetes management regimen.24 It is also recognized that patients substantially fear the recurrence of nocturnal hypoglycemia, which may reduce their adherence to insulin therapy.23 Furthermore, nocturnal hypoglycemia may also contribute toward (i) the impaired awareness of future hypoglycemic events, which, in turn, may increase the risk of major hypoglycemia,25,26 and (ii) terminal conditions, such as “dead-in-bed” syndrome.27 This evidence concerns the gene INS and Hypoglycemia.