This general trend was retained after 21 days, albeit at slightly reduced levels: OM caused a 1.8-fold increase in RUNX2 expression in AB cells and PRF resulted in a 2.6-fold increase in RUNX2 expression in AB cells, while there was little effect in the other two progenitor cell populations (Figure 4(e)). This evidence concerns the gene RUNX2 and ocular melanoma.