The master regulatory networks of human embryonic stem cell (hESC) transcription factors, OCT4, SOX2, and NANOG, as well as other cell fate determining transcription factors that are implicated in stem cell self-renewal capacities, such as NOTCH1 and STAT3, are expressed not only by embryonic stem cells, but also by a number of cancers [1]. The gene discussed is NOTCH1; the disease is cancer.