To test this hypothesis and further understand the pathogenesis of DCM, we investigated 10 tagging SNPs in the TNNT2 gene in DCM patients and normal control subjects from a Chinese Han population using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) techniques. This evidence concerns the gene TNNT2 and familial dilated cardiomyopathy.