In conclusion, we showed that FX has a beneficial effect in inhibiting fat accumulation in liver, improves insulin resistance and glucose disposal, inhibits inflammation, and possesses a repressive property on hepatic lipogenesis, which are associated with the inhibition of ChREBP and SREBP-1c, and induction of PPARα, suggesting a potential application of FX in treating fatty liver diseases. Here, MLXIPL is linked to Insulin resistance.