MLXIPL and Insulin resistance: Excess fat accumulation ultimately leads to hepatic steatosis and worsening hepatic insulin resistance via a network of transcription factors [8], which regulate hepatic lipogenesis and fatty acid oxidation, including carbohydrate responsive element binding protein (ChREBP), sterol regulatory element-binding protein-1c (SREBP-1c), liver X receptor (LXR), and peroxisome proliferator-activated receptor (PPAR).