The current meta-analysis showed a significant relationship between adiponectin −11377CG gene polymorphism and T2DM under the allelic (OR: 1.150), recessive (OR: 1.450), dominant (OR: 1.071), additive (OR: 1.280), and homozygous genetic models (OR: 1.620). Here, ADIPOQ is linked to type 2 diabetes mellitus.