There was a significant relationship between adiponectin −11377CG gene polymorphism and T2DM under the allelic (OR: 1.150, 95% CI: 1.060–1.250, P = 0.001), recessive (OR: 1.450, 95% CI: 1.180–1.770, P = 0.0004), dominant (OR: 1.071, 95% CI: 1.013–1.131, P = 0.015), additive (OR: 1.280, 95% CI: 1.090–1.510, P = 0.002), and homozygous genetic models (OR: 1.620, 95% CI: 1.310–1.990, P<0.00001). The gene discussed is ADIPOQ; the disease is type 2 diabetes mellitus.