Finally, insulin-stimulated glucose transport was strongly reduced in the gastrocnemious as well as in the tibialis and quadriceps skeletal muscle of TgPed/pea-15mice injected with either vehicle or Ad-GFP compared to control mice, whilst infection of Ad-D4 resulted in a marked increase of the glucose uptake to levels comparable to those of controls (Figure 5a, b, c). This evidence concerns the gene INS and infection.