To determine whether changes in cholesterol metabolism induced by the decrease of brain SCAP protein might alter synaptic transmission, we performed intracellular and extracellular electrophysiological recordings from neurons in the area CA1 region of the hippocampus, an area of the brain with demonstrated abnormalities on imaging in humans with type 1 and type 2 diabetes [7],[8]. Here, SCAP is linked to type 2 diabetes mellitus.