To determine the consequences of reduced SCAP content in the brain in the absence of diabetes, we created mice with homozygous and heterozygous loss of SCAP specifically in the brain by crossing mice carrying a modified Scap gene with LoxP sites surrounding exon 1 [10] with mice expressing Cre-recombinase under control of the rat nestin promoter and enhancer [11]. Here, NES is linked to diabetes mellitus.