In contrast to this, Koornstra et al. [9] describe a lack of correlation of DR4 and DR5 cytoplasmic expression with grading and staging in cancer of the colon, and Zhuang et al. [28] found DcR1 and DcR2 cytoplasmic expression not to be related to progression of neoplasmic disease. The gene discussed is TNFRSF10C; the disease is neoplasm.