For example, in the Reduction of Infarct Expansion and Ventricular Remodeling With Erythropoietin After Large Myocardial Infarction (REVEAL) study involving patients with acute myocardial infarction, a single injection of epoietin alfa (60 000 IU) was associated with poor CV outcomes without differences in hematocrit levels between the control and the treated group.30 Here, EPO is linked to acute myocardial infarction.